The journey from Vellore to Salem spans approximately 160 kilometers via the well-maintained NH 48 and NH 44. You can reach Salem in about 3 hours by car or 4 hours by bus. The route passes through Krishnagiri and Dharmapuri, offering scenic views of the Eastern Ghats. Frequent state-run SETC buses and private operators connect these two major industrial hubs. Trains are also available, though bus travel is often more flexible due to higher frequency.
Total Distance: 160 km by road, 145 km air distance.
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Direct
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Direct
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| Duration | 3 hours 30 mins | 4 hours |
| Avg Price | 150-600 INR | 250-450 INR |
| Operator | Kaveri Express | SETC Tamil Nadu |
| Route | Katpadi Junction to Salem Junction. | NH 48 to Krishnagiri, then NH 44 to Salem. |
| Tip | Book tickets in advance as this is a busy route for commuters. | Board at the Vellore New Bus Stand for frequent departures. |
October to March for pleasant weather during the drive.